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Take E19 to Antwerp from Brussels, Amsterdam, Rotterdam and Breda. Take E16 from Gent to Antwerp. Take E313/E34 from Eindhoven and Turnhout to Antwerp.
Take exit 3 on R1 Ring Highway. At the traffic light, turn left and pass under a bridge while heading toward Plantin en Moretuslei. At the seventh traffic light, turn right onto the Quinten Matsijslei. The City Park is on the left. Go straight until the next traffic light and turn right onto the Quellinstraat. Follow this street to the third traffic light and turn right at a large square with lots of buses. Go straight until the large Astridplein square.
Parking is available for EUR 19 per day in the private parking garage of the Radisson Blu Astrid Hotel (100 metres away). To reach this parking, continue past the Radisson Blu Hotel and take an immediate left into the Van Schoonhovenstraat. Stop at the third gate on the left. The gate will automatically open, providing access to parking. For GPS, enter: Van Schoonhovenstraat, 2018 Antwerp.
A second parking option is the public Q-Park under the Astrid Square in front of the hotel.